The Relationship between the Levels of Anti Cyclic Citrullinated Protein Antibodies Type2 (ACPA2) and the Severity of Erosive Rheumatoid Arthritis (RA)

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M. Jnad
K. Aldou
H. Yazaji


Background: Rheumatoid arthritis (RA) is a chronic systemic disease, characterized by autoimmunity. One of the most specific and important diagnostic and prognostic markers of RA are antibodies, Anti Cyclic Citrullinated Protein Antibodies (ACPA).

Objective: The purpose of this study was to investigate the association between ACPA (Anti-CCP) levels and radiological damage.

Methods: An observational Cross-sectional study included 54 patients fulfilling the ACR-EULAR 2010 criteria for RA, with minimum disease duration of 1 year. Radiographs were scored using a modified Sharp score (Van der Heijde modification of Sharp's score 1989). ACPA levels were determined using immunofluorescence assay.

Results: ACPA levels were strongly associated with radiographic severity and there was a significant relationship between ACPA levels and total Sharp score (p=0.0001).

Conclusion: This study concluded that ACPA is an independent severity factor for RA, and our data supports the association between ACPA and radiographic severity.

Anti cyclic citrullinated protein, Type2 (ACPA2), rheumatoid arthritis, systemic disease.

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Jnad, M., Aldou, K., & Yazaji, H. (2020). The Relationship between the Levels of Anti Cyclic Citrullinated Protein Antibodies Type2 (ACPA2) and the Severity of Erosive Rheumatoid Arthritis (RA). Asian Journal of Immunology, 4(3), 28-33. Retrieved from
Original Research Article


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