Asian Journal of Immunology

A Case Report on Rhupus Syndrome

Ariba *

Department of Medicine, Jawaharlal Nehru Medical College, AMU, Aligarh, India.

Ahmad Ghayas Ansari

Department of Medicine, Jawaharlal Nehru Medical College, AMU, Aligarh, India.

M. Aslam

Department of Medicine, Jawaharlal Nehru Medical College, AMU, Aligarh, India.

*Author to whom correspondence should be addressed.

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Abstract

Rheumatoid arthritis and systemic lupus erythematosus are two extremely common autoimmune illnesses that cause disability and poor quality of life. The innate immune system, a topic in autoimmune disorders that has long been neglected, is becoming more significant and represents a new area of attention for the treatment of these conditions [1].

People with systemic lupus erythematosus (SLE) who also exhibit symptoms of another rheumatologic disorder, such as rheumatoid arthritis, Sjogren's syndrome, and/or vasculitis, are said to have overlap syndromes [2]. Rhupus Syndrome is a rare condition that shares traits with both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Even if there have been case reports before, the condition is still more uncommon in men than in women.

Here, we present the case scenario of a middle-aged male presenting with Rhupus syndrome and muscle weakness as the primary complaints. He was initiated on steroid and his improvement was recorded after a 6 week follow up. Physicians should thus, remain alert to manifestations of autoimmunity and features of overlap syndromes.

Keywords: Rhupus syndrome, systemic lupus erythematosis, rheumatoid arthritis, overlap syndromes

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References

Pabón-Porras MA, Molina-Ríos S, Flórez-Suárez JB, Coral-Alvarado PX, Méndez-Patarroyo P, Quintana-López G. Rheumatoid arthritis and systemic lupus erythematosus: Pathophysiological mechanisms related to innate immune system. SAGE Open Med. 2019;7: 205031211987614. DOI: 10.1177/2050312119876146

Bacalao MA, Bermas BL. Overlap syndromes. In: Lahita’s Systemic Lupus Erythematosus. Elsevier. 2021:423-430.

DOI: 10.1016/B978-0-12-820583-9.00028-2

Ahsan H. Rhupus: Dual rheumatic disease. J Immunoassay Immunochem. 2022;43(2):119-128.

DOI: 10.1080/15321819.2021.1941096

Antonini L, Le Mauff B, Marcelli C, Aouba A, de Boysson H. Rhupus: A systematic literature review. Autoimmun Rev. 2020; 19(9):102612. DOI: 10.1016/j.autrev.2020.102612

Upadhyaya S, Agarwal M, Upadhyaya A, Pathania M, Dhar M. Rhupus Syndrome: A Diagnostic Dilemma. Cureus; 2022. DOI: 10.7759/cureus.29018

Paramasivam S, Noh MM, Khaing MS, Dahlan IM, Payus AO. An uncommon cause of myalgia: A case report on systemic lupus erythematous myopathy. Ann Med Surg. 2022;75. DOI: 10.1016/j.amsu.2022.103450

Jakati S, Rajasekhar L, Uppin M, Challa S. SLE myopathy: A clinicopathological study. Int J Rheum Dis. 2015;18(8):886-891. DOI: 10.1111/1756-185X.12592

Rubini E, Foddai SG, Radin M, et al. AB1177 How to define rhupus syndrome: Systematic review of the current literature. In: Abstracts Accepted for Publication. BMJ Publishing Group Ltd and European League Against Rheumatism; 2019;2049: 2-2050. DOI:10.1136/annrheumdis-2019-eular.7042