Asian Journal of Immunology

Rheumatoid arthritis and systemic lupus erythematosus are two extremely common autoimmune illnesses that cause disability and poor quality of life. The innate immune system, a topic in autoimmune disorders that has long been neglected, is becoming more significant and represents a new area of attention for the treatment of these conditions [1].

People with systemic lupus erythematosus (SLE) who also exhibit symptoms of another rheumatologic disorder, such as rheumatoid arthritis, Sjogren's syndrome, and/or vasculitis, are said to have overlap syndromes [2]. Rhupus Syndrome is a rare condition that shares traits with both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Even if there have been case reports before, the condition is still more uncommon in men than in women.

Here, we present the case scenario of a middle-aged male presenting with Rhupus syndrome and muscle weakness as the primary complaints. He was initiated on steroid and his improvement was recorded after a 6 week follow up. Physicians should thus, remain alert to manifestations of autoimmunity and features of overlap syndromes.