Pharmacology of Vaccines against Coronavirus Disease in Clinical Use Globally: A Review
Published: 2023-08-02
Page: 153-162
Issue: 2023 - Volume 6 [Issue 1]
Casimir C. Ofor *
Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Ebonyi State University, Abakaliki, Nigeria.
Godwin C. Akuodor
Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Eugene O. Ohanme
Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Alex Ekwueme Federal University, Abakaliki, Ebonyi State, Nigeria.
Chikere Anusiem
Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Following the lethal nature of the coronavirus disease and the high transmissibility of the disease, a concerted effort has been made throughout the world to produce viable and affordable vaccines to curb the impact of the disease globally. Various technologies have employed in the process of developing vaccines against the coronavirus disease. Adverse events following immunization is very common in patients receiving immunological and biological products. These events are characterized by some serious clinical manifestations in the patients.
Over three thousand, five hundred adverse events reports were made by clients receiving some coronavirus vaccines in the United States of America by the center for disease control in June, 2021. Some of the features manifested by the patients include: convulsions, irregular heart beats, serious abdominal discomfort and signs resembling cerebrovascular accidents.
Well over one thousand case reports of inflammation of the heart muscles and the pericardium were reported to the Vaccine Adverse Events Reporting system following the inoculation with mRNA-based coronavirus vaccine produced by Moderna and Pfizer-BioNtech pharmaceutical companies in the United States of America (USA) according to the CDC reports in April, 2021.
Keywords: Coronavirus vaccine, SARS-Cov2, immunology, disease, adverse events