Asian Journal of Immunology http://www.journalaji.com/index.php/AJI <p style="text-align: justify;"><strong>Asian Journal of&nbsp;Immunology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJI/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of the immune system in all organisms. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;"><img src="/public/site/images/sciencedomain/free-sign.gif" width="69" height="28"></p> <p style="text-align: justify;"><strong>Publication Charge: FREE</strong>. All the manuscripts submitted within this month will be published free of cost. There is no publication charge for this month.&nbsp;</p> en-US contact@journalaji.com (Asian Journal of Immunology) contact@journalaji.com (Asian Journal of Immunology) Thu, 09 Jan 2020 11:03:09 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 High Rates of Birth Defects in Fallujah, Iraq: Radiological and Chemical Pollution of the Affected Children and their Parents http://www.journalaji.com/index.php/AJI/article/view/30103 <p><strong>Background</strong><strong>:</strong> Lack of birth registers hindered knowledge of the frequency of birth defects (BD) in Fallujah, Iraq and comparison of changes in prevalence in time. One study found correlation between BD presentation and teratogenic metal load [1].</p> <p><strong>Methods</strong><strong>: </strong>We obtained reproductive history, kin health, environmental exposure and historical residence of families. Hair was sampled from the nape of the neck from families and analyzed by ICP/MS for metal content.</p> <p><strong>Findings</strong><strong>:</strong> BD in newborn in 2010 were about 14.7% [2]. Data of reproductive history from 56 couples with child, overcoming the lack of previous data, shows pattern of increase in BD presentation since 1991. Information on parent's immediate kin in more than 1000 people, supports that BD are sporadic events. High residential stability of families allows to rule out local clusters for BD. Focus on load for ten teratogenic and carcinogenic metals (V, Cr, Co, As, Mo, Cd, W, U, Hg, Pb) in hair of 43 BD children and 103 their parents, and of 11 healthy newborns and 16 their parents, compared with that of 10 children and 8 adults controls outside the war area, shows that metal contamination is diffuse in the whole Fallujah population and is present already in newborn children hair. Absolute levels of major teratogenic and carcinogenic contaminants (V, Co, Mo, U and Pb) were significantly higher in Fallujah people than in controls from other areas, with Pb levels in BD children higher than other newborns in Fallujah.</p> <p><strong>Interpretation:</strong> Unusual high prevalence progressive in time and increased load of teratogenic metals even in new born hair are reported in Fallujah population. The extensive metal contamination persistent in people's hair in post-war environment and the composite metal load might be a major factor in the increase in time of stochastic events that lead to BD presentation.</p> Samira Telfah Abdulghani Alaani, Mohammad Tafash, Abdulkadir Abdulkareem Murie, Allawi Muhyee Al-Esawi ##submission.copyrightStatement## http://www.journalaji.com/index.php/AJI/article/view/30103 Thu, 09 Jan 2020 00:00:00 +0000 Effects of D-Ribose-L-Cysteine on Lipid Profile, Atherogenic Index and Infertility in Streptozotocin-Induced Male Diabetic Wistar Rats http://www.journalaji.com/index.php/AJI/article/view/30104 <p><strong>Aims:</strong> The present study aimed at determining the effects of D-Ribose-L-Cysteine on lipid profile, atherogenic index, and infertility in streptozotocin-induced diabetic male Wistar rats.&nbsp;</p> <p><strong>Methods:</strong> A total of twenty-eight adult male Wistar rats were divided into four groups of seven rats each. 1: Normal control group, 2: Diabetic control group, 3: Normal rats treated with 30 mg/kg body weight of D-Ribose-L-cysteine, 4: Diabetic rats treated with 30 mg/kg body weight of D-Ribose-L-cysteine. Group 2 and 4 were injected intraperitoneally with a single dose of streptozotocin (STZ) (65 mg/kg in 0.1 M cold citrate buffer, pH 7.5) prior to D-Ribose-L-cysteine treatment. Group 4 were subsequently administered D-Ribose-L-cysteine orally 72 hours post administration of streptozotocin, twice daily for 28 days. Parameters tested include: fasting blood and serum glucose, malondialdehyde (MDA) concentration, sperm motility, morphology and count. Testosterone (TT), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were also examined.</p> <p><strong>Results:</strong> The results showed that diabetic rats showed weights loss, increased MDA, increase blood and serum glucose levels, elevated lipid profile, altered TT, FSH and LH as well as reduced sperm count, motility and morphology. These effects were ameliorated in diabetic rats treated with D-Ribose-L-cysteine.</p> <p><strong>Conclusion: </strong>Current study revealed that D-Ribose-L-Cysteine attenuates the oxidative stress in streptozotocin-induced diabetic rats on blood glucose, lipid profile, reproductive hormone and sperm parameters.</p> Abiodun Oluwabusola Adedeji, Patrick Kunle Orisadiran ##submission.copyrightStatement## http://www.journalaji.com/index.php/AJI/article/view/30104 Mon, 20 Jan 2020 00:00:00 +0000 Impact of Exercise on Some Haematological and Cellular Immune Markers in Male Athletes http://www.journalaji.com/index.php/AJI/article/view/30105 <p>Due to conflicting reports on the impact of exercise on haematological and immunological indices, this study investigated the effects of exercise on some haematological and cellular immune markers in male athletes. Blood samples were collected from 86 apparently healthy male athletes before and after exercise training using standardized methods. Similarly, blood samples were obtained from 100 male non-athletes and served as control. Blood samples collected from athletes and non-athletes were subjected to experimental evaluation of some haematological and cellular immune biomarkers using standard techniques. Results showed that, with the exception of neutrophils that significantly increased after exercise in athletes, lymphocytes, monocytes, eosinophils and clusters of differentiation counts significantly (p&lt;0.05) decreased in athletes after exercise. Also, with the exception of platelets, other haematological parameters assayed in this study significantly (p&lt;0.05) decreased in athletes after exercise.&nbsp; However, there was no significant change in these parameters between athletes at rest and non-athletes. This study concludes that heavy training could lead to an open window of immunodepression leading to susceptibility to infection in athletes and non-athletes alike.</p> K. U. Nwoke, F. S. Amah-Tariah, A. N. Chuemere ##submission.copyrightStatement## http://www.journalaji.com/index.php/AJI/article/view/30105 Mon, 03 Feb 2020 00:00:00 +0000